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Biophysical Studies of the Actin-Myosin Motor System and Applications


Congratulations to  Mohammad Ashikur Rahman, who graduated on September 05, 2019!


This thesis shows that actin is a dynamic filament upon myosin binding and this information is useful when using actin filaments for Biocomputing.

To control actin filament velocity myosin inhibitors, such as blebbistatin, can be useful for the in vitro motility assays in biocomputation network.

Presence of dead myosin heads negatively affect the actin filament gliding in the in vitro motility assay used in a biocomputation network. This thesis describes and analyses two methods to remove the dead heads to provide good quality assay with nearly 100% fraction of motile filaments recovered.

Biocomputation devices are expensive and time consuming to produce. This thesis describes a method where it is shown that the use of proteinase K with a suitable detergent can be useful to recycle nanodevices for several times.

This thesis studied different ways to immobilize engineered light controlled myosin motor on TMCS derivatized surfaces that shed lights to develop a future programmable gate for a biocomputation network.

Energy-efficient biocomputers & €5.000 Biocomputing Award

– 2 Bio4Comp Webinars

Did you know that in 2015 the world’s data centers consumed more energy than the entire UK?


Today’s computers use vast amounts of electricity – so much so that not being able to cool the processors actually hampers the development of more powerful computers. In addition, they cannot do two things at the same time, which affects the processing speed needed. There is an urgent need to increase computing power and decrease their energy consumption.

Now, imagine a high-performance computing cluster that runs on a few kilograms of biochemical fuel instead of megawatts of electrical power. This may sound like science fiction now, but in principle, it is actually possible, thanks to network-based biocomputing.


Biocomputing uses a system of organic molecules, such as proteins and DNA, to form complex calculations involving the processing, storage, and retrieval of data. This emerging technology can greatly reduce the energy consumption of computation is high demand, while at the same time increasing their computing power. This is a promising technology that is turning into a viable alternative computing approach.


Bio4Comp is organising a webinar on the 3rd September, 11:00 AM CEST on how next-generation biocomputers can overcome the limitations of electrical computing by integrating DNA and microfluidics-based computation.


Who are the speakers?

  • Till Korten (TU Dresden), expert in biophysics of single motor proteins, will introduce the concept of performing logical operations with motor proteins that explore physical networks.
  • Cordula Reuther (TU Dresden), expert in nanotechnological applications of molecular motor systems, specifically microtubules and kinesin motors. One challenge for scaling up network-based biocomputation is to increase the number of filaments as they pass through biocomputational networks. Here, Cordula will advise us of the latest results on multiplying microtubules..
  • Roman Lyttleton (Lund University), expert in integration of electrical detection systems with molecular motor assays will talk about recent developments in using field-effect transistors for detection of unbound agents for network-based biocomputation.

 

REGISTER NOW! The 1-hour webinar is free and open to all.


Call for Computer Scientists: €5,000 Prize for Novel Biocomputing Ideas


The scientific community is facing challenges related to two key trends: the big data revolution and the impressive increase in computational power. It is crucial to maximize the effectiveness of computational efforts across the world.

Bio4Comp launched the open call “Bio4Comp Open Innovation Award”, where €5,000 will be awarded to the most novel idea that conceptually or technically advances the field of parallel computing with biological agents in a substantial manner.

Do you have an idea on how to produce computers that are faster and vastly consume less energy or resources? Join Bio4Comp webinar on 24th September, 11:00 AM CEST, to learn how ideas to solve the most pressing Biocomputing problems can help you win €5,000


Who are the speakers?

  • Heiner Linke, (Lund University), professor of Nanophysics, will introduce the Bio4Comp Open Innovation Award.
  • Danny Reuter (Fraunhofer-ENAS) a Microtechnology researcher and will announce the 1st Bio4Comp Open Innovation Award Winner, and summarize the ideas of the runners up.
  • Adam Micolich (UNSW) Nanoelectronics Professor, will present the Winning Idea: Colorimetric path tagging of laments using DNA-based meta fluorophores
  • Hillel Kugler (Faculty of Engineering at Bar-Ilan University) presents the “Bio4Comp 2nd Call for Ideas: Design and Visualization of NBC algorithms” and how you can apply to the €5.000 Award.

 

REGISTER NOW! The 1-hour webinar is free and open to all.


Why should you join the webinar?

  • Find out about the latest developments in network-based biocomputation.
  • Engage in the “Biocomputing Network” and showcase your own work.
  • Understand the mechanics of the “€5,000 Prize for Novel Biocomputing Ideas” award and how to join.
  • Join free of charge and in 1 hour be inspired by the alternative use of biomolecules and nanofabrication for developing low-energy computing.

Research Results

On 7th June 2019, Frida Lindberg defended her doctoral thesis in front of an international committee of examiners and opponent Dr. Mihai Irimia-Vladu from Joanneum Research in Austria. "The energy efficient computing of the biological molecules is an important contribution to sustainable chip technology." said Dr. Irimia-Vladu during his overview talk.  


Two important techological developments form

the cornerstones of Frida Lindberg's doctoral thesis:

  • the surface chemistry of the devices, which is
    altered in order to enable re-use and
  • a more efficient fabrication method

 

See also Publications

TRAINING: APPLY FOR TRAVEL SUPPORT

 

For you who are interested to learn methods in biocomputation, we are offering hands-on training;

travel support available; read more and apply under Training  


RESULTS: PUBLICATIONS

 

Scientific publications that have resulted from this project, can now be found under Publications

Photo: Ines Escherich

ARTWORK: SMART>SOS

 

SMART>SOS is a video and sound installation revealing the new paradigm of computation based on the research performed in Bio4Comp. Follow the realization of this exciting artwork at imachination projects.

 

This co-production with the artist Tim Otto Roth was possible thanks to the VERTIGO-project. This initiative facilitates cooperation between artists and research projects within information and computation technologies. The proposal SMART>SOS by Tim Otto Roth has been selected by an international jury of experts for cooperation with Bio4Comp.

 

The addition of sound and the use of the Bio4Comp technology in an artistic  way adds a new dimension to biocomputation which makes the computational processes visually and acoustically tangible. The work with the artist during phase one of the project, inspired the researchers to new insights.

 

The walkable light and sound installation “SMART>SOS” was shown during the celebrations of the 10th anniversary of Bio4Comp partner Fraunhofer Institute for Electronic Nano Systems (ENAS) in Chemnitz on October 17, 2018. The event was held at the Event and Conference Site “Kraftverkehr”, a former repair hall for public transportation with the largest free-standing roof of all industrial buildings in East Germany. Roughly 300 guests followed the invitation to this event, amongst them the Prime Minister of Saxony (Michael Kretschmer), the Lord Mayor of Chemnitz (Barbara Ludwig), and the President of the Fraunhofer Society (Prof. Reimund Neugebauer).

 

„SMART>SOS” was part of the exhibition “Fraunhofer and Arts”

which was shown during the celebration in the entrance part

of the Conference Hall.

 

The picture shows guests of the event gathering under the

loudspeakers of the SMART>SOS installation. A video

recorded through fluorescence microscopy imaging shows

molecular agents travelling a real (artistic, yet working)

biocomputation network made on nanopatterned and

functionalized microfluidic substrates; it is projected onto

the floor of the Conference Hall.

IN THE PRESS

 

See what others are writing about Bio4Comp here

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This project has received funding from the European Union’s

Horizon 2020 research and innovation programme under grant agreement No 732482.

Call: FETPROACT-2016; Type of Action: RIA (Research and Innovation Action)

Page Manager: Gerda Rentschler, e-mail